CEFIOFF – Cefixime 200 mg + Ofloxacin 200 mg Tablets

CEFIOFF by Amcare Pharmaceuticals is a prescription antibacterial combination containing Cefixime IP equivalent to Cefixime Anhydrous 200 mg and Ofloxacin IP 200 mg per film-coated tablet.

CEFIOFF Composition

Each film-coated tablet contains:

• Cefixime IP equivalent to Cefixime Anhydrous – 200 mg
• Ofloxacin IP – 200 mg
• Excipients – q.s.
• Colour – Titanium Dioxide IP

CEFIOFF Product Details

CEFIOFF Uses

CEFIOFF contains two antibacterial agents and should be prescribed only when the combination is considered appropriate for the suspected or confirmed bacterial infection.

India’s CDSCO approved fixed-dose combinations of Cefixime 100/200 mg + Ofloxacin 100/200 mg for treatment of typhoid fever and urinary tract infection in adults.

Antibacterial medicines should be used only for bacterial infections and not for viral illnesses such as the common cold or influenza.

CEFIOFF Benefits

• Contains Cefixime 200 mg + Ofloxacin 200 mg
• Combines two antibacterial agents with different mechanisms of action
• Film-coated tablet formulation
• Convenient oral dosage form
• Available in a 10 × 10 tablet pack

How Does CEFIOFF Work?

Cefixime in CEFIOFF

Cefixime is a cephalosporin antibacterial that interferes with bacterial cell-wall synthesis, helping inhibit the growth of susceptible bacteria.

Ofloxacin in CEFIOFF

Ofloxacin belongs to the fluoroquinolone class of antibacterials. It works by interfering with bacterial enzymes required for DNA replication and repair.

CEFIOFF Antibacterial Action

The combination provides antibacterial activity through the actions of cefixime and ofloxacin. Selection of this combination should be based on the clinical diagnosis and appropriate medical assessment.

CEFIOFF Dosage and Administration

The dosage and duration of treatment should be determined by the prescribing healthcare professional based on the infection, patient characteristics and clinical condition.

• Take exactly as prescribed.
• Swallow the tablet with water unless otherwise directed.
• Complete the prescribed treatment course.
• Do not self-medicate with antibiotics.
• Patients with kidney impairment may require individualized dosing.

CEFIOFF Side Effects

Possible side effects may include:

• Nausea
• Vomiting
• Diarrhea
• Abdominal discomfort
• Headache
• Dizziness
• Indigestion

Because CEFIOFF contains ofloxacin, important fluoroquinolone-related adverse effects can include tendon injury, peripheral neuropathy and central nervous system effects. Ofloxacin labeling also warns about QT-interval prolongation and other serious reactions.

CEFIOFF Precautions and Warnings

Inform your healthcare professional if you:

• Have an allergy to cefixime, ofloxacin or other beta-lactam/quinolone antibiotics.
• Have a history of tendon disorders.
• Have peripheral neuropathy.
• Have epilepsy or other CNS disorders.
• Have kidney problems.
• Have a prolonged QT interval or certain heart-rhythm problems.
• Are taking corticosteroids or medicines that may affect heart rhythm.
• Are pregnant or breastfeeding.

Ofloxacin carries specific warnings for tendinitis/tendon rupture, peripheral neuropathy, CNS effects and worsening of myasthenia gravis.

CEFIOFF Storage

• Store according to the instructions on the product packaging.
• Protect from excessive heat, moisture and direct sunlight.
• Keep the tablets in the original packaging.
• Keep out of reach of children.

Why Choose CEFIOFF by Amcare Pharmaceuticals?

CEFIOFF by Amcare Pharmaceuticals provides a combination of Cefixime 200 mg and Ofloxacin 200 mg in a convenient film-coated tablet formulation for prescription use.