ACNE QUEEN Gel – Clindamycin 1% w/w + Nicotinamide 4% w/w

4. What is ACNE QUEEN Gel used for?

ACNE QUEEN is intended for the topical management of acne vulgaris, subject to its approved product information and a healthcare professional’s recommendation.

Potential treatment goals include:

• Managing inflammatory acne lesions, such as red pimples and pustules.

• Reducing acne-associated bacterial activity.

• Supporting improvement in acne-related skin inflammation.

• Helping manage acne as part of a broader skincare and treatment plan.

Clindamycin topical products are indicated for acne vulgaris. The specific indications for ACNE QUEEN should be confirmed against its approved Indian product information.

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Important: This product should not be advertised as a guaranteed cure for acne, a treatment for every type of pimple, or a proven method of removing acne scars.

5. How does ACNE QUEEN work?

Clindamycin 1% w/w

Clindamycin is a lincosamide antibiotic. It binds to the bacterial 50S ribosomal subunit and inhibits protein synthesis in susceptible bacteria.

In acne treatment, its role is to reduce susceptible bacteria associated with inflammatory acne, particularly Cutibacterium acnes, and help manage inflammatory lesions.

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Nicotinamide 4% w/w

Nicotinamide, or niacinamide, is a form of vitamin B3 used in topical skincare. It may support the skin barrier and help improve the appearance of skin affected by inflammation.

The precise clinical benefit of the 4% concentration in this specific combination cannot be established from the packaging alone.

Aloe-Allantoin gel base

The artwork identifies an aloe-allantoin gel base. It provides the vehicle for applying the active ingredients to the skin. The packaging alone does not establish a specific clinical outcome for the base.

Mechanism summary

Clindamycin → Inhibition of susceptible bacterial protein synthesis → Reduced bacterial activity associated with inflammatory acne.

Nicotinamide → Supportive topical skincare role → May help support the skin barrier and improve the appearance of irritated skin.

6. Which acne lesions may benefit?

Acne can appear in several forms:

A topical clindamycin formulation is primarily relevant to inflammatory acne. Deep, painful, widespread or scarring acne may require a different or additional treatment plan.

Do not assume that ACNE QUEEN alone is suitable for every acne type.

7. How to use ACNE QUEEN Gel

Follow the directions provided by the prescribing clinician and the approved product leaflet.

General application guidance:

1. Clean the affected skin gently and allow it to dry.

2. Apply a thin layer to the prescribed acne-affected area.

3. Avoid the eyes, lips, inside of the nose and other mucosal surfaces.

4. Wash your hands after application.

5. Use only for the prescribed duration.

The artwork does not specify a product-specific application frequency or treatment duration. Do not publish a fixed regimen as the approved ACNE QUEEN dose without verifying its package insert.

8. Antibiotic stewardship: an important consideration

ACNE QUEEN contains topical clindamycin, so antibiotic resistance must be considered.

Acne guidelines generally advise against using topical antibiotics alone for prolonged periods. Benzoyl peroxide is commonly incorporated into acne treatment regimens to help reduce the development of antibiotic resistance. ACNE QUEEN’s supplied composition does not list benzoyl peroxide. A dermatologist should therefore determine whether an additional non-antibiotic acne treatment is appropriate.

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Recommended website wording:

Use ACNE QUEEN Gel only as directed by a healthcare professional. Avoid prolonged or repeated unsupervised use. Your dermatologist may recommend additional non-antibiotic acne treatment as part of your treatment plan.

9. Possible side effects

Possible local effects associated with topical clindamycin and acne gels include:

• Skin dryness

• Burning or stinging

• Itching

• Redness

• Peeling

• Skin irritation

• Contact dermatitis

Topical clindamycin has also been associated rarely with diarrhoea and antibiotic-associated colitis.

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Stop using the product and seek medical advice if you develop significant irritation, swelling or a severe rash. If persistent or severe diarrhoea, bloody stools or severe abdominal cramps occur during treatment, discontinue use and seek urgent medical advice.

10. Precautions and warnings

• For external use only.

• Do not apply to the eyes or mucosal surfaces.

• Do not use if you have a known allergy to clindamycin, lincomycin or any ingredient in the formulation.

• Inform your doctor if you have a history of ulcerative colitis, regional enteritis or antibiotic-associated colitis.

• Avoid prolonged, frequent or repeated use without medical advice.

• Do not share the tube with another person.

• Keep the product away from children.

Topical clindamycin is contraindicated in patients with certain histories of antibiotic-associated colitis and inflammatory bowel disease according to its prescribing information.

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11. Pregnancy and breastfeeding

Consult a healthcare professional before using ACNE QUEEN during pregnancy or breastfeeding. The decision should consider the treatment area, the extent of use and the approved product information.

Avoid applying the gel to the breast or any area that could come into direct contact with an infant’s mouth.

12. Use in children and adolescents

Acne treatment in younger patients should be guided by a qualified healthcare professional. The supplied artwork does not specify a minimum age or a paediatric dosing regimen.

Do not publish an age-specific claim without checking the approved product information.

13. Skin-care advice during acne treatment

Patients using ACNE QUEEN may be advised to:

• Use a gentle cleanser.

• Avoid harsh scrubs and excessive exfoliation.

• Choose non-comedogenic moisturisers and sunscreen.

• Avoid picking or squeezing pimples.

• Introduce other active skincare products only with appropriate guidance.

• Follow the prescribed treatment duration.

Acne improvement can take time. Persistent, worsening or scarring acne should be reassessed by a dermatologist.

14. Frequently asked questions

What is ACNE QUEEN Gel?

ACNE QUEEN is a topical gel containing Clindamycin 1% w/w and Nicotinamide 4% w/w in an aloe-allantoin gel base.

What is ACNE QUEEN used for?

It is intended for the topical management of acne vulgaris, particularly inflammatory acne, according to the approved product information.

Does ACNE QUEEN contain an antibiotic?

Yes. Clindamycin is a topical antibiotic.

Does ACNE QUEEN contain niacinamide?

Yes. Nicotinamide is another name for niacinamide, a form of vitamin B3.

Can ACNE QUEEN remove acne scars?

The supplied composition does not establish that the product removes established acne scars. Acne scars may require separate assessment and treatment.

Can I use ACNE QUEEN for a long time?

Do not use it for longer than prescribed. Prolonged or repeated antibiotic use without medical supervision may contribute to antimicrobial resistance.

What is the pack size?

The displayed pack is 20 g.