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ALREE-5 Tablets
Levocetirizine Dihydrochloride 5 mg
ALREE-5 is an oral antihistamine tablet containing Levocetirizine Dihydrochloride IP 5 mg per tablet. It is used for the symptomatic management of allergic conditions, particularly symptoms such as sneezing, runny nose, nasal/ocular itching and allergic skin manifestations.
1. Product Information
| Parameter | Details |
|---|---|
| Brand Name | ALREE-5 |
| Generic Name | Levocetirizine Dihydrochloride |
| Strength | 5 mg |
| Dosage Form | Uncoated Tablet |
| Route | Oral |
| Therapeutic Category | Antihistamine / Anti-allergic |
| Pack Size | 20 × 10 Tablets |
| Prescription Status | Rx, as shown on artwork |
Composition
Each uncoated tablet contains:
- Levocetirizine Dihydrochloride IP — 5 mg
- Excipients — q.s.
2. What is ALREE-5 Used For?
ALREE-5 contains levocetirizine, a selective H1-antihistamine used to relieve symptoms associated with allergic conditions.
It may be used for symptomatic relief of:
- Allergic rhinitis
- Seasonal allergic rhinitis
- Perennial allergic rhinitis
- Sneezing
- Runny nose
- Nasal itching
- Itchy or watery eyes
- Throat/nasal itching
- Allergic skin symptoms
- Urticaria (hives)
Official levocetirizine labeling describes its use for allergic-rhinitis symptoms and the uncomplicated skin manifestations of chronic idiopathic urticaria.
3. Mechanism of Action
Levocetirizine Dihydrochloride 5 mg
Levocetirizine is the active R-enantiomer of cetirizine and acts primarily as a peripheral H1-histamine receptor antagonist.
During an allergic reaction, histamine contributes to symptoms such as:
Histamine release
↓
H1 receptor activation
↓
Sneezing + itching + runny nose + watery eyes + other allergic symptoms
Levocetirizine blocks H1-receptor-mediated effects:
Levocetirizine
↓
H1 receptor blockade
↓
Reduced histamine-mediated symptoms
This helps provide symptomatic relief from allergic manifestations.
4. Therapeutic Benefits
✔ Helps relieve sneezing
By reducing histamine-mediated stimulation of nasal sensory pathways.
✔ Helps reduce runny nose
Reduces histamine-mediated nasal secretions associated with allergic reactions.
✔ Helps relieve nasal itching
Reduces histamine-related itching and irritation.
✔ Helps relieve itchy/watery eyes
Can reduce ocular symptoms associated with allergic rhinitis.
✔ Helps control allergic skin symptoms
Levocetirizine is also used for the uncomplicated skin manifestations of chronic idiopathic urticaria.
✔ Convenient once-daily antihistamine
The standard adult strength is 5 mg, with dosing dependent on age, indication and renal function.
5. Common Clinical Applications
| Condition / Symptom | Therapeutic Role |
|---|---|
| Allergic rhinitis | Symptomatic relief |
| Seasonal allergies | Symptomatic relief |
| Perennial allergic rhinitis | Symptomatic relief |
| Sneezing | Antihistamine action |
| Runny nose | Antihistamine action |
| Nasal itching | Antihistamine action |
| Itchy/watery eyes | Antihistamine action |
| Urticaria / hives | Reduction of allergic skin symptoms |
| Allergy-associated itching | Symptomatic relief |
6. Allergic Rhinitis
Allergic rhinitis can produce symptoms including:
- Repeated sneezing
- Runny nose
- Nasal itching
- Nasal congestion
- Itchy eyes
- Watery eyes
Levocetirizine helps control the histamine-mediated component of these symptoms.
It does not eliminate the underlying allergen or cure the allergic tendency.
7. Urticaria / Hives
Urticaria is characterized by:
- Itchy raised skin lesions
- Redness
- Wheals
- Recurrent itching
Histamine is an important mediator in many urticarial reactions.
Levocetirizine blocks H1 receptors and can therefore help reduce the itching and other uncomplicated skin manifestations associated with chronic idiopathic urticaria.
8. Suggested Use & Dosage
The artwork confirms the 5 mg strength, but it does not provide a dosing schedule.
For your product page, the safest wording is:
Take ALREE-5 Tablets as directed by the physician.
For reference, current professional labeling for levocetirizine 5 mg states that adults and children 12 years and older may receive 5 mg once daily, while lower doses are used in younger children and patients with renal impairment.
Administration
- Take orally with water.
- It may be taken with or without food.
- Follow the prescribed dose and duration.
- Do not exceed the recommended dose.
Because levocetirizine is substantially eliminated through the kidneys, dose adjustment may be necessary in patients with impaired renal function.
9. Side Effects
Levocetirizine is generally well tolerated, but some patients may experience:
Commonly reported effects
- Drowsiness
- Fatigue
- Headache
- Dry mouth
- Dizziness
Drowsiness, fatigue and asthenia have been reported with levocetirizine.
Less common reactions
- Gastrointestinal discomfort
- Nausea
- Abdominal discomfort
- Skin reactions
Rare but serious allergic reactions
Seek immediate medical attention for:
- Facial swelling
- Lip or tongue swelling
- Difficulty breathing
- Severe skin reaction
- Signs of anaphylaxis
10. Drowsiness & Driving
Although levocetirizine is considered less sedating than many older antihistamines, drowsiness can occur.
Patients should determine how the medicine affects them before:
- Driving
- Operating machinery
- Working at heights
- Performing tasks requiring complete alertness
Official labeling advises caution with hazardous activities requiring mental alertness.
11. Alcohol & CNS Depressants
Alcohol and other central nervous system depressants may increase drowsiness or impairment.
Therefore, patients should avoid or limit alcohol while taking levocetirizine, particularly if they experience sedation.
12. Precautions & Warnings
Inform the physician before using ALREE-5 if the patient has:
- Kidney disease
- Difficulty urinating
- Enlarged prostate
- Previous allergy to levocetirizine
- Previous allergy to cetirizine
- Significant drowsiness with antihistamines
Patients with renal impairment require particular attention because levocetirizine is substantially eliminated by the kidneys.
13. Contraindications
ALREE-5 should not be used in patients with known hypersensitivity to:
- Levocetirizine
- Cetirizine
- Any component of the formulation
Current professional labeling also contraindicates levocetirizine in patients with end-stage renal disease or those undergoing hemodialysis.
For your final Indian product literature, contraindications should be checked against the current approved Indian package insert.
14. Drug Interactions
Inform the doctor about all medicines being taken.
Particular attention should be given to:
Alcohol
May increase drowsiness.
Sedatives
May increase CNS depression.
Tranquilizers
May increase impairment.
Other antihistamines
May increase antihistamine-related adverse effects.
Other medicines causing drowsiness
Combined effects may impair alertness.
15. Pregnancy & Breastfeeding
Use during pregnancy or breastfeeding should be based on medical advice.
Patients who are:
- Pregnant
- Planning pregnancy
- Breastfeeding
should inform their healthcare professional before taking ALREE-5.
16. Use in Elderly Patients
Elderly patients may have reduced renal function and may therefore require individualized dosing.
They may also be more susceptible to:
- Drowsiness
- Dizziness
- Urinary retention
Renal function should be considered when determining the appropriate dose.
17. Renal Impairment
This is an important consideration for levocetirizine.
Because the drug is substantially excreted through the kidneys, patients with reduced renal function may require dose adjustment.
Patients with severe renal impairment or those undergoing hemodialysis should not use levocetirizine unless specifically determined appropriate by their treating healthcare professional.
18. Hepatic Impairment
Levocetirizine is primarily eliminated through the kidneys.
Current prescribing information indicates that hepatic impairment alone generally does not require dose adjustment, but patients with combined hepatic and renal impairment may require adjustment because renal function affects levocetirizine clearance.
19. When to Seek Medical Attention
Seek urgent medical attention if the patient develops:
- Difficulty breathing
- Swelling of the face, lips or tongue
- Severe allergic reaction
- Severe dizziness or loss of consciousness
- Severe or unusual skin reaction
- Significant difficulty passing urine
If excessive drowsiness or impairment occurs, avoid driving and seek medical advice.
20. Storage
Store ALREE-5 Tablets:
- In a cool, dry place.
- Away from direct sunlight.
- Away from excessive heat and moisture.
- In the original packaging.
- Out of reach of children.
Do not use after the expiry date.
21. Key Product Features
ALREE-5 Tablets
Single-ingredient antihistamine formulation
- Levocetirizine Dihydrochloride IP — 5 mg
- Oral tablet
- Antihistamine / anti-allergic
- Useful for symptomatic management of allergic conditions
- Supports relief of sneezing, runny nose and itching
- Used in appropriate patients with urticaria
- 20 × 10 Tablets
- Rx product as shown on artwork
22. Why Choose ALREE-5?
Levocetirizine 5 mg
A well-established second-generation antihistamine used for allergic conditions.
Broad allergy symptom coverage
It can address several histamine-mediated symptoms, including:
Sneezing + Runny Nose + Nasal Itching + Ocular Symptoms + Allergic Itching
Convenient dosage strength
The product provides 5 mg levocetirizine dihydrochloride per tablet.
Single active ingredient
The formulation contains one active pharmaceutical ingredient, allowing therapy to be directed specifically toward histamine-mediated allergic symptoms.ALREE-5 Tablets | Levocetirizine 5 mg
