COFFMUL LS Junior Syrup – Complete Product Information

1. Product Overview

COFFMUL LS Junior Syrup by Amcare Pharmaceuticals is a combination respiratory syrup containing Levosalbutamol Sulphate, Ambroxol Hydrochloride and Guaiphenesin.

According to the supplied product artwork, each 5 mL contains:

• Levosalbutamol Sulphate IP — equivalent to Levosalbutamol 0.5 mg

• Ambroxol Hydrochloride IP — 15 mg

• Guaiphenesin IP — 50 mg

• Flavoured Syrup Base — Q.S.

The packaging identifies the flavour as Delicious Cherry Flavour. Amcare’s published product listing also identifies a 60 mL pack.

The ingredients have complementary respiratory actions: Levosalbutamol is a bronchodilator, Ambroxol is a mucolytic, and Guaiphenesin is an expectorant. The combination is intended for selected respiratory conditions involving mucus and airway narrowing, subject to the product’s approved indications.

Important paediatric safety note: India’s 2025 Ministry of Health advisory states that cough and cold medicines should not be prescribed or dispensed to children under two years and are generally not recommended for children under five years. Use in older children should follow careful clinical assessment, appropriate dosing and medical supervision.

2. Product Composition

Product Details

3. What is COFFMUL LS Junior Syrup?

COFFMUL LS Junior Syrup combines a bronchodilator with a mucolytic and an expectorant.

Levosalbutamol

Relaxes airway smooth muscle and helps improve airflow when bronchospasm is present.

Ambroxol Hydrochloride

Helps reduce mucus viscosity, making respiratory secretions easier to clear.

Guaiphenesin

Helps thin mucus and makes it easier to cough up.

The combination is most relevant to selected respiratory conditions involving mucus congestion and airway narrowing. A CDSCO document lists this same combination and strength for symptomatic relief of bronchospasm in bronchial asthma and chronic bronchitis; the current authorisation and approved indications for the specific marketed product must still be verified.

4. Active Ingredient Profile

A. Levosalbutamol — 0.5 mg per 5 mL

Levosalbutamol is a selective beta-2 adrenergic agonist bronchodilator.

Main role: Bronchodilation

It relaxes the smooth muscles surrounding the airways, helping widen narrowed bronchial passages.

Potential effects include:

• Improved airflow when bronchospasm responds to treatment

• Relief of wheezing associated with reversible airway narrowing

• Reduced airway resistance

Levosalbutamol does not thin mucus directly.

Safety considerations: Tremor, nervousness, headache, palpitations and rapid heartbeat are recognised adverse effects of levalbuterol medicines.

B. Ambroxol Hydrochloride — 15 mg per 5 mL

Ambroxol is a mucolytic medicine used for respiratory conditions associated with thick or difficult-to-clear mucus.

Main role: Mucus thinning

It helps reduce the viscosity of mucus and supports its removal from the respiratory tract.

Potential roles include:

• Helping loosen thick respiratory secretions

• Supporting mucus clearance

• Making phlegm easier to expectorate

• Supporting the management of selected respiratory conditions involving abnormal mucus

Ambroxol does not act as a bronchodilator.

Precaution: Rare allergic and severe skin reactions have been reported with ambroxol. A progressive rash, blistering or lesions involving the mouth or other mucous membranes require prompt medical attention.

C. Guaiphenesin — 50 mg per 5 mL

Guaiphenesin is an expectorant used to help relieve chest congestion.

Main role: Expectorant / Mucus clearance

It helps thin mucus in the air passages so that secretions can be coughed up more easily.

Potential roles include:

• Helping loosen thick mucus

• Supporting expectoration

• Helping clear respiratory secretions

• Relieving symptoms associated with chest congestion

Guaiphenesin provides symptomatic relief; it does not treat the underlying cause of a respiratory illness.

5. What is COFFMUL LS Junior Used For?

Based on its ingredients, COFFMUL LS Junior may be considered for selected respiratory conditions involving mucus congestion and bronchospasm, subject to the approved product indication and the patient’s clinical assessment.

Productive Cough

Ambroxol and Guaiphenesin help loosen mucus and support its clearance.

Chest Congestion

The mucolytic and expectorant components support the removal of thick respiratory secretions.

Wheezing Associated with Bronchospasm

Levosalbutamol relaxes airway smooth muscle and may improve airflow when bronchospasm is present.

Selected Respiratory Conditions

The combination may be relevant where both difficult-to-clear mucus and airway narrowing are present.

Important: These are ingredient-based uses, not confirmation of every approved indication for COFFMUL LS Junior. The exact indications should be checked against the current product licence and package insert.

6. How Does COFFMUL LS Junior Work?

The three ingredients have complementary mechanisms.

Levosalbutamol → Airway Relaxation

Airway smooth-muscle contraction

↓

Beta-2 receptor activation

↓

Relaxation of bronchial muscles

↓

Improved airflow when bronchospasm responds to treatment

Ambroxol → Mucus Thinning

Thick respiratory mucus

↓

Reduced mucus viscosity

↓

Easier transport of respiratory secretions

↓

Improved mucus clearance

Guaiphenesin → Expectorant Action

Mucus in the airways

↓

Mucus becomes easier to cough up

↓

Support for expectoration

Combined Action

In simple terms: COFFMUL LS Junior combines airway-relaxing activity with support for mucus thinning and clearance.

7. Product Highlights

Three-ingredient respiratory formulation: Contains Levosalbutamol, Ambroxol Hydrochloride and Guaiphenesin.

Bronchodilator action: Levosalbutamol relaxes airway smooth muscle.

Mucolytic action: Ambroxol helps make thick mucus easier to clear.

Expectorant action: Guaiphenesin helps loosen mucus and supports expectoration.

Cherry flavour: The supplied product artwork identifies Delicious Cherry Flavour.

60 mL pack: Amcare’s published product page lists a 60 mL pack.

8. Dry Cough vs. Productive Cough

Understanding the type of cough helps guide treatment.

Productive or Wet Cough

A productive cough brings up mucus or phlegm. Ambroxol and Guaiphenesin support mucus thinning and clearance.

Dry or Non-productive Cough

A dry cough produces little or no mucus. A formulation designed around mucus clearance and bronchodilation may not be appropriate for every dry cough.

COFFMUL LS Junior

The ingredient profile is most relevant to selected conditions involving thick mucus and bronchospasm, rather than every type of cough.

9. Dosage and Administration

The appropriate dose and duration must be determined from the approved COFFMUL LS Junior product information and a healthcare professional’s instructions.

The supplied artwork shows the ingredients and strengths but does not establish a complete approved age-wise dosing schedule.

General administration precautions:

• Shake the syrup before use if instructed on the label.

• Measure each dose accurately with an appropriate medicine-measuring device.

• Follow the prescribed dose, frequency and duration.

• Do not use an ordinary household spoon for precise measurement.

• Do not exceed the prescribed dose.

• Do not combine with another cough or respiratory medicine without checking its ingredients.

• Seek medical advice if symptoms persist or worsen.

Do not infer a child’s dose from the strength alone. The child’s age, clinical condition and approved product instructions must be considered.

10. Paediatric Safety and Age Restrictions

Although the artwork uses the name Junior, that name alone does not establish the minimum approved age.

India’s Ministry of Health advisory issued in October 2025 states that cough and cold medicines should not be prescribed or dispensed to children under two years and are generally not recommended for children under five. For older children, use should follow careful clinical evaluation, supervision and appropriate dosing.

Additionally, a report published on 6 October 2026 states that India’s Drugs Consultative Committee had recommended a general warning against cough syrup use in children below four years, with the government considering the proposal. The report describes a proposed change, not a confirmed final amendment. The current notified requirements should therefore be checked before updating packaging.

For COFFMUL LS Junior, verify the exact approved minimum age, indication and dosing schedule before publishing paediatric-use claims.

11. Possible Side Effects

Side effects may arise from any of the three active ingredients.

Levosalbutamol-related effects

Potential effects include:

• Tremor or shaking

• Nervousness

• Headache

• Palpitations

• Rapid heartbeat

• Dizziness

• Sleep disturbance

Tremor, tachycardia, palpitations, headache and dizziness are recognised adverse effects of levalbuterol medicines.

Ambroxol-related effects

Potential effects include:

• Nausea

• Vomiting

• Gastrointestinal discomfort

• Skin rash

• Hypersensitivity reactions

Rare severe allergic and skin reactions have been reported.

Guaiphenesin-related effects

Potential effects include:

• Nausea

• Vomiting

• Headache

The actual adverse-effect profile of COFFMUL LS Junior should be checked against its approved prescribing information.

12. Important Safety Information

Cardiovascular Precautions

Because the formulation contains Levosalbutamol, particular caution may be necessary in patients with:

• Heart disease

• Fast or irregular heartbeat

• Hypertension

• Hyperthyroidism

• Diabetes

Levosalbutamol can cause palpitations, tremor and a rapid heartbeat.

Electrolyte Considerations

Beta-2 agonists can lower blood potassium levels in certain clinical situations. The treating clinician should consider relevant risk factors and interacting medicines.

Severe Skin Reactions

Stop treatment and seek prompt medical advice if a progressive rash, blistering or lesions affecting the mouth or other mucous membranes occur during ambroxol treatment.

Respiratory Symptoms

COFFMUL LS Junior should not be used as a substitute for prescribed emergency treatment for an acute asthma attack or sudden, severe breathing difficulty.

13. Precautions

Medical advice should be obtained before use in patients with:

• Cardiovascular disease

• Hypertension

• Hyperthyroidism

• Diabetes

• Kidney or liver impairment

• History of peptic ulcer disease

• Known hypersensitivity to any ingredient

• Persistent or unexplained cough

• Chronic respiratory disease requiring ongoing treatment

The exact contraindications and precautions should be verified from the approved COFFMUL LS Junior package insert.

14. Drug Interaction Considerations

Tell the prescribing healthcare professional about all medicines currently being used.

Other Bronchodilators or Sympathomimetics

Medicines with similar adrenergic activity may increase the risk of tremor, palpitations or cardiovascular effects.

Beta-blockers

Beta-blockers may oppose the bronchodilator effects of beta-2 agonists and can be problematic in some patients with bronchospastic conditions.

Certain Antidepressants

Some medicines, including tricyclic antidepressants and monoamine oxidase inhibitors, may potentiate cardiovascular effects of beta-2 agonists.

Other Respiratory Medicines

Check other cough or respiratory formulations carefully to avoid unnecessary duplication of bronchodilators, mucolytics or expectorants.

15. When to Consult a Doctor

Medical evaluation is recommended if the patient develops:

• Persistent or worsening cough

• Severe wheezing

• Difficulty breathing

• Chest pain

• Rapid or irregular heartbeat

• Severe dizziness or fainting

• Cough with blood

• Persistent fever

• Severe or rapidly worsening symptoms

• A significant rash, blistering or swelling

Sudden or severe breathing difficulty requires urgent medical attention.

16. Storage and Handling

Store COFFMUL LS Junior according to the conditions specified on the approved product label.

General precautions include:

• Keep the bottle tightly closed.

• Protect from excessive heat and direct sunlight.

• Keep out of reach of children.

• Check the expiry date before use.

• Do not use if the bottle or seal is damaged.

• Follow the manufacturer’s instructions for storage after opening.

The exact storage temperature and in-use shelf life should be obtained from the approved product information.

17. Packaging Information

The supplied artwork shows:

• Dark pharmaceutical bottle

• Golden-coloured cap

• White label with red and gold accents

• Respiratory/lung illustration

• COFFMUL LS Junior Syrup branding

• Delicious Cherry Flavour

• Amcare branding

The published Amcare product page lists the packaging as 60 mL.